Why the study?
Does losartan alter afferent aortic nerve activity in rats with coarctation hypertension?
Population
Rats with coarctation hypertension induced by subdiaphragmatic aortic coarctation, and sham-operated groups
Comparison
Losartan (10 mg/kg per day p.o.) for 8 days vs Vehicle
Design
Preclinical
Follow-up
8 days
Authors
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AT1 blockade may preserve baroreceptor sensitivity in hypertensive rats; leaves open clinical relevance for human baroreflex function.
Does losartan alter afferent aortic nerve activity in rats with coarctation hypertension?
AT1 receptor blockade with losartan improves the sensitivity of aortic afferents in a rat model of chronic hypertension, suggesting angiotensin II contributes to reduced baroreceptor gain.
Santos et al. (1998) studied this question.
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