Why the study?
Does losartan alter autonomic balance and sympathetic responses in a rat model of coarctation hypertension?
Population
Rats with hypertension induced by subdiaphragmatic aortic coarctation, and sham-operated controls
Comparison
Losartan 10 mg/kg per day PO for 9 days vs Vehicle
Design
Preclinical
Follow-up
9 days
Authors
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Losartan may modulate autonomic balance independent of BP in experimental hypertension; leaves open translation to human coarctation or essential hypertension.
Does losartan alter autonomic balance and sympathetic responses in a rat model of coarctation hypertension?
Angiotensin II acts via AT1 receptors to alter sympathovagal balance during the establishment of coarctation hypertension, independent of preexisting pressure levels.
Bezerra et al. (2001) studied this question.
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