Why the study?
Does chronic losartan treatment alter vascular reactivity in normotensive rats?
Does chronic losartan treatment alter vascular reactivity in normotensive rats?
Chronic losartan administration in normotensive rats reduces blood pressure and attenuates angiotensin II-mediated potentiation of vascular tone in resistance arteries.
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Chronic losartan attenuates Ang II-potentiated tone in normotensive rat vessels; hypothesis-generating and leaves open clinical translation.
Dowell et al. (1997) studied this question.
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