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November 1, 1995AJP Regulatory Integrative and Comparative Physiology

ANG II receptor blockade and arterial baroreflex regulation of renal nerve activity in cardiac failure

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Why the study?

Does losartan improve arterial baroreflex regulation of efferent renal sympathetic nerve activity in rats with congestive heart failure?

Population

Conscious control (C) and congestive heart failure (CHF) rats

Comparison

Intravenous losartan and intracerebroventricular… vs Control rats and baseline pre-losartan values

Design

Preclinical

Authors

GDGerald F. DiBonaGeneral CardiologySJSusan Y. JonesUniversity of IowaVBVirginia L. BrooksOregon Health & Science University

Discussion

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Implication

Losartan may restore baroreflex control of renal sympathetic activity in experimental CHF; leaves open translation to human heart failure therapy.

Structured PICO

Does losartan improve arterial baroreflex regulation of efferent renal sympathetic nerve activity in rats with congestive heart failure?

P
Population
Conscious control (C) and congestive heart failure (CHF) rats
I
Intervention
Intravenous losartan (10 mg/kg, 21.7 mumol/kg) and intracerebroventricular losartan (4.61 micrograms, 10 nmol)
C
Comparator
Control rats and baseline pre-losartan values
O
Outcome
Arterial baroreflex regulation of efferent renal sympathetic nerve activity (ERSNA) and maximal gain (Gmax)surrogate

Angiotensin II receptor blockade with losartan improves the attenuated arterial baroreflex regulation of renal sympathetic nerve activity in a rat model of congestive heart failure.

Cite This Study

DiBona et al. (1995) studied this question.

synapsesocial.com/papers/6a775027576efb0ddaf73febhttps://doi.org/10.1152/ajpregu.1995.269.5.r1189

Topics

Heart failureHFrEF treatment
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effect of endogenous angiotensin II on renal nerve activity and its cardiac baroreflex regulation.1998 · 20 citations
  2. 2Angiotensin receptor antagonist improves cardiac reflex control of renal sodium handling in heart failure1998 · 49 citations
  3. 3Effect of endogenous angiotensin II on renal nerve activity and its arterial baroreflex regulation1996 · 62 citations
  4. 4Brain renin-angiotensin system and sympathetic hyperactivity in rats after myocardial infarction1999 · 107 citations
  5. 5Blockade Of Central Angiotensin II Does Not Affect The Reduction In Renal Sympathetic Nerve Activity Following A Volume Load In Heart Failure Rabbits2000