Why the study?
Does losartan improve cardiac baroreflex regulation of renal sympathetic nerve activity and renal sodium handling in rats with nephrotic syndrome?
Population
Rats with nephrotic syndrome (arterial baroreceptor-intact and arterial baroreceptor-denervated)
Design
Preclinical
Authors
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Hypothesis-generating in experimental nephrotic syndrome; leaves open clinical translation and human trials.
Does losartan improve cardiac baroreflex regulation of renal sympathetic nerve activity and renal sodium handling in rats with nephrotic syndrome?
In a rat model of nephrotic syndrome, losartan improved cardiac baroreflex regulation of renal sympathetic nerve activity and enhanced the ability to excrete acute sodium loads.
Sánchez-Palacios et al. (1998) studied this question.
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