April 1, 2001HypertensionOpen Access

Sodium Intake Influences Hemodynamic and Neural Responses to Angiotensin Receptor Blockade in Rostral Ventrolateral Medulla

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Why the study?

Does sodium intake influence hemodynamic and neural responses to angiotensin receptor blockade in the rostral ventrolateral medulla of rats?

Population

Anesthetized rats consuming a low, normal, or high sodium diet, and a subset of rats with congestive heart…

Comparison

Microinjection of angiotensin II type 1 receptor… vs Responses compared across different sodium diets.

Design

Preclinical

Authors

GDGerald F. DiBonaGeneral Cardiology SJSusan Y. JonesUniversity of Iowa

Discussion

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Implication

Sodium intake may modulate ARB sympathoinhibitory effects in rats; hypothesis-generating and should not change clinical practice.

Structured PICO

Does sodium intake influence hemodynamic and neural responses to angiotensin receptor blockade in the rostral ventrolateral medulla of rats?

Population

Anesthetized rats consuming a low, normal, or high sodium diet, and a subset of rats with congestive heart failure.

Intervention

Microinjection of angiotensin II type 1 receptor antagonists (losartan 50, 100, and 200 pmol; candesartan 1, 2, and 10 pmol) or [D-Ala(7)]Angiotensin-(1-7) (100, 200, and 1000 pmol) into the rostral ventrolateral medulla.

Comparator

Responses compared across different sodium diets (low, normal, high).

Outcome

Changes in mean arterial pressure, heart rate, and renal sympathetic nerve activity (RSNA).surrogate

Physiological alterations in endogenous renin-angiotensin system activity via sodium intake influence hemodynamic and renal sympathoinhibitory responses to AT1 receptor blockade in the rostral ventrolateral medulla.

Cite This Study

DiBona et al. (2001) studied this question.

synapsesocial.com/papers/6a7e575e2fd85368b24d8f48 https://doi.org/10.1161/01.hyp.37.4.1114

Topics

Heart failure HFrEF treatment

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Sodium Intake Influences Hemodynamic and Neural Responses to Angiotensin Receptor Blockade in Rostral Ventrolateral Medulla

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Sodium Intake Influences Hemodynamic and Neural Responses to Angiotensin Receptor Blockade in Rostral Ventrolateral Medulla

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider