Why the study?
Does intracerebroventricular losartan alter the baroreceptor control of renal sympathetic nerve activity in normotensive and hypertensive rats?
Population
Wistar rats fed either a regular or high-salt diet, and stroke-prone spontaneously hypertensive rats
Comparison
Intracerebroventricular administration of losartan vs Baseline (before administration of losartan)
Design
Preclinical
Authors
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Central AT1 blockade augments baroreflex sensitivity in hypertensive rat models; hypothesis-generating for brain RAS in human autonomic control.
Does intracerebroventricular losartan alter the baroreceptor control of renal sympathetic nerve activity in normotensive and hypertensive rats?
In conscious rats, the tonic inhibitory action of brain angiotensin II on baroreflex regulation of renal sympathetic nerve activity is enhanced in stroke-prone spontaneously hypertensive rats but unaffected by high dietary sodium.
Huang et al. (2006) studied this question.
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