Why the study?
Does a high salt diet differentially modulate the arterial baroreceptor reflex in normotensive versus spontaneously hypertensive rats?
Population
Six-week-old normotensive Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR)
Comparison
High salt diet (8.00%) for 4 weeks vs Normal salt diet (0.66%) for 4 weeks
Design
Preclinical
Follow-up
4 weeks
Authors
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Differential salt-baroreflex effects in rat strains are hypothesis-generating; leaves open human relevance for salt-sensitive hypertension.
Does a high salt diet differentially modulate the arterial baroreceptor reflex in normotensive versus spontaneously hypertensive rats?
A high salt diet differentially modulates the central mechanism of baroreflex control of sympathetic activity, potentiating it in normotensive rats but impairing it in spontaneously hypertensive rats.
Ono et al. (1997) studied this question.
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