Key result
A high salt diet with normal calcium significantly increased mean arterial pressure and renal sympathetic nerve activity and impaired the arterial baroreceptor reflex in spontaneously hypertensive rats.
Why the study?
Does a high calcium diet prevent baroreflex impairment in salt-loaded spontaneously hypertensive rats?
Population
Six-week-old spontaneously hypertensive rats (SHR)
Comparison
High calcium diet combined with high salt diet… vs Normal salt / normal calcium diet, and high salt…
Design
Preclinical
Follow-up
4 weeks
Authors
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These rat data should not change practice; they leave open whether calcium supplementation mitigates salt-induced baroreflex impairment in human hypertension.
Does a high calcium diet prevent baroreflex impairment in salt-loaded spontaneously hypertensive rats?
Ono et al. (1994) studied Hypertension. High calcium diet vs. Normal calcium diet (1.17%) was evaluated on Mean arterial pressure, renal sympathetic nerve activity, heart rate, and arterial baroreceptor reflex. A high salt diet with normal calcium significantly increased mean arterial pressure and renal sympathetic nerve activity and impaired the arterial baroreceptor reflex in spontaneously hypertensive rats.
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