Key result
Dietary salt loading for 5 weeks in rats produced mild hypertension and selectively inhibited chronotropic baroreflex responses to phenylephrine, while preserving decreases in renal nerve activity.
Why the study?
Does a high-salt diet induce hypertension and baroreflex impairment in Sprague-Dawley rats?
Population
Sprague-Dawley rats
Comparison
High-salt diet for 5 weeks vs Control rats
Design
Preclinical
Follow-up
5 weeks
Authors
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High-salt diets may selectively blunt baroreflex heart-rate control in rats; leaves open translation to human salt-sensitive hypertension.
Does a high-salt diet induce hypertension and baroreflex impairment in Sprague-Dawley rats?
In a rat model, dietary salt loading induces mild hypertension and selectively impairs aortic baroreceptor-mediated chronotropic responses without altering renal nerve activity.
Miyajima et al. (1985) studied Hypertension. High-salt diet vs. Control diet was evaluated on Chronotropic baroreflex sensitivity and blood pressure. Dietary salt loading for 5 weeks in rats produced mild hypertension and selectively inhibited chronotropic baroreflex responses to phenylephrine, while preserving decreases in renal nerve activity.
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