Hypothesis-generating in prehypertensive SHR; leaves open baroreflex role in human genetic hypertension and should not change practice.
Objective: Previous studies have shown that arterial baroreceptor reflex control of sympathetic nerve activity is blunted in salt-dependent hypertensive model in prehypertensive stage(such as Dahl-S and DOCA-salt rats). The arterial baroreflex control of sympathetic nerve activity in prehypertensive SHR, a genetic model of hypertension, has been little known. This study tested the hypothesis that there is impairment in arterial baroreflex function in conscious SHR. We recorded the lumbar sympathetic nerve activity(LSNA) in prehypertensive SHR and WKY during phenylephrine injection under unanesthetized and free-moving conditions. Methods: This study was performed in 5-week old(Prehypertensive;n=6) and 10-week
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Kasamatsu et al. (1995) studied this question.
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