What question did this study set out to answer?

To evaluate the effects of nitric oxide on blood pressure and renal sympathetic nerve activity responses elicited by angiotensin II blockade in conscious spontaneously hypertensive rats.

April 1, 1993Hypertension

Role of nitric oxide and angiotensin II in the regulation of sympathetic nerve activity in spontaneously hypertensive rats.

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Why the study?

Does Ang II blockade and nitric oxide inhibition alter baroreceptor reflex function and sympathetic nerve activity in spontaneously hypertensive rats?

Population

Conscious spontaneously hypertensive rats

Comparison

Acute intravenous administration of losartan… vs Vehicle

Design

Preclinical

Follow-up

acute

Authors

HKHitoshi KumagaiToyota Central Research and Development Laboratories (Japan)DADavid B. AverillGeisinger Commonwealth School of Medicine MKM. C. KhoslaColumbia University

Discussion

Member takes

Implication

Supports AT1 blockade restoring baroreflex gain in SHR; leaves open translation to human hypertension therapy.

Key Points

To evaluate the effects of nitric oxide on blood pressure and renal sympathetic nerve activity responses elicited by angiotensin II blockade in conscious spontaneously hypertensive rats.
Measured mean arterial pressure, heart rate, and renal sympathetic nerve activity using implanted electrodes in conscious spontaneously hypertensive rats.
Determined baroreceptor reflex gain using logistic function curves after acute intravenous administration of vehicle, losartan, CGP 42112A, lisinopril, or the nitric oxide synthase inhibitor NG-monomethyl L-arginine (10 mg/kg).
Losartan (-1.8 ± 0.3%/mm Hg) and lisinopril (-2.4 ± 0.2%/mm Hg) significantly increased the maximum gain of baroreceptor reflex control of renal sympathetic nerve activity compared to vehicle (-1.1 ± 0.2%/mm Hg; p < 0.05), whereas CGP 42112A produced no significant change.
Nitric oxide synthase inhibition elevated baseline blood pressure and reduced renal nerve activity; subsequent losartan or lisinopril restored blood pressure to initial hypertensive levels while increasing renal sympathetic nerve activity above baseline.

Structured PICO

Does Ang II blockade and nitric oxide inhibition alter baroreceptor reflex function and sympathetic nerve activity in spontaneously hypertensive rats?

Population

Conscious spontaneously hypertensive rats

Intervention

Acute intravenous administration of losartan (Ang II type 1 receptor antagonist), CGP 42112A (type 2 antagonist), or lisinopril (ACE inhibitor), with or without NG-monomethyl L-arginine (10 mg/kg)

Comparator

Vehicle

Outcome

Baroreceptor reflex function (maximum gain of the baroreceptor reflex control of nerve activity), mean arterial pressure, heart rate, and renal sympathetic nerve activitysurrogate

In spontaneously hypertensive rats, blunted baroreceptor reflex function is mediated by the Ang II type 1 receptor, and its blockade improves reflex gain.

Cite This Study

Kumagai et al. (1993) studied this question.

synapsesocial.com/papers/6a70c80fa528af2d65c3bb74 https://doi.org/10.1161/01.hyp.21.4.476

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Role of nitric oxide and angiotensin II in the regulation of sympathetic nerve activity in spontaneously hypertensive rats.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Role of nitric oxide and angiotensin II in the regulation of sympathetic nerve activity in spontaneously hypertensive rats.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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