Key result
Exogenous Angiotensin II resets the baroreceptor reflex control of heart rate to a higher pressure but does not increase resting renal sympathetic nerve activity.
Why the study?
Does Angiotensin II differentially affect renal sympathetic nerve activity and heart rate in conscious rabbits?
Population
Conscious rabbits
Comparison
Exogenous Angiotensin II and losartan vs Phenylephrine and nitroprusside infusions
Design
Preclinical
Authors
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Ang II suppresses RSNA without equivalent bradycardia in rabbits; leaves open differential baroreflex mechanisms in human hypertension.
Does Angiotensin II differentially affect renal sympathetic nerve activity and heart rate in conscious rabbits?
Effect estimate: decreased by 67 +/- 13%
p-value: p=<0.01
Exogenous Angiotensin II resets the baroreceptor reflex control of heart rate to a higher pressure but does not increase resting renal sympathetic nerve activity or alter its baroreceptor reflex control in conscious rabbits.
Kumagai et al. (1994) studied Conscious rabbits (animal model). Angiotensin II vs. Phenylephrine and baseline was evaluated on Renal sympathetic nerve activity (decreased by 67 +/- 13%, p=<0.01). Exogenous Angiotensin II resets the baroreceptor reflex control of heart rate to a higher pressure but does not increase resting renal sympathetic nerve activity.
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