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September 10, 1968Acta Physiologica Scandinavica

Effect of Angiotensin on Sympathetic Nerve Activity

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Why the study?

Does i.v. infusion of angiotensin affect sympathetic nerve activity and blood pressure compared to noradrenalin in rabbits?

Population

13 rabbits

Comparison

I.v. infusion of angiotensin (0.5–3 μg/kg. min) vs Infusion of noradrenalin

Design

Preclinical

Authors

HAH. AarsOslo University HospitalSAS. AkreUniversity of Oslo

Discussion

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Implication

Transient sympathetic activation by angiotensin does not sustain BP rise; leaves open central mechanisms in chronic hypertension models.

Key Points

  • To study how angiotensin affects sympathetic nerve activity and blood pressure in rabbits.
  • 13 rabbits were tested with intravenous infusion of angiotensin (0.5–3 μg/kg.min) and compared to noradrenalin infusion.
  • Blood pressure and renal and cervical sympathetic nerve activities were recorded during the experiment.
  • Angiotensin infusion initially reduced normal sympathetic activity but resulted in transient non-rhythmical activity associated with a temporary increase in blood pressure.
  • Unlike noradrenalin, which maintained decreased sympathetic activity throughout, the effects of angiotensin were brief and diminished after a few minutes.

Structured PICO

Does i.v. infusion of angiotensin affect sympathetic nerve activity and blood pressure compared to noradrenalin in rabbits?

P
Population
13 rabbits
I
Intervention
I.v. infusion of angiotensin (0.5–3 μg/kg. min)
C
Comparator
Infusion of noradrenalin
O
Outcome
Renal and cervical sympathetic nerve activities and blood pressuresurrogate

Angiotensin induces a transient, nervously mediated increase in blood pressure via central sympathetic neurons, but this effect is of minor importance for the blood pressure response to prolonged infusion in rabbits.

Cite This Study

Aars et al. (1968) studied this question.

synapsesocial.com/papers/6a708243a528af2d65c3951chttps://doi.org/10.1111/j.1365-201x.1968.tb10908.x
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Also Consider

Synapse has enriched one closely related paper. Consider it for comparative context:

  1. 1Evidence for a Central Mechanism in Angiotensin Induced Hypertension.1961 · 384 citations