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December 1, 1970Experimental Biology and Medicine

Effect of Angiotensin on the Cardioaccelerator Response to Sympathetic Nerve Stimulation in Isolated Rabbit Hearts

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Why the study?

Does angiotensin infusion increase the accelerator response to sympathetic nerve stimulation in perfused rabbit hearts?

Population

Perfused rabbit hearts

Comparison

Angiotensin infusions vs Before angiotensin infusions

Design

Preclinical

Authors

JTJ. L. ThompsonVictor Chang Cardiac Research Institute

Discussion

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Implication

Angiotensin potentiates sympathetic responses in isolated rabbit hearts; leaves open relevance to human cardiovascular physiology or therapy.

Structured PICO

Does angiotensin infusion increase the accelerator response to sympathetic nerve stimulation in perfused rabbit hearts?

P
Population
Perfused rabbit hearts
I
Intervention
Angiotensin infusions
C
Comparator
Before angiotensin infusions
O
Outcome
Accelerator response to sympathetic nerve stimulationsurrogate

Angiotensin increases the cardioaccelerator response to sympathetic nerve stimulation in isolated rabbit hearts, likely by potentiating norepinephrine release.

Cite This Study

J. L. Thompson (1970) studied this question.

synapsesocial.com/papers/6a8c8067e2daec1d82d3cda9https://doi.org/10.3181/00379727-135-35152
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effect of Angiotensin on Sympathetic Nerve Activity1968 · 1 citations
  2. 2Effect of Angiotensin on Sympathetic Nerve Activity1968 · 36 citations
  3. 3The influence of angiotensin on the uptake of noradrenaline by the isolated heart of the rabbit1970 · 30 citations
  4. 4Peripheral Presynaptic Facilitatory Effect of Angiotensin II on Noradrenaline Release in Anesthetized Rabbits1990 · 35 citations
  5. 5Evidence that angiotensin enhances transmitter release during sympathetic nerve stimulation1971 · 197 citations