Key result
Angiotensin II infusion enhanced pressor responses in hypertensive patients compared to normotensives (P<0.05) and impaired baroreflex control of muscle sympathetic nerve activity and heart rate.
Why the study?
Does angiotensin II infusion alter baroreflex control of muscle sympathetic nerve activity and heart rate compared to phenylephrine in hypertensive and normotensive subjects?
Population
Patients with essential hypertension and normotensive subjects
Comparison
Intravenous infusion of Angiotensin II for 10… vs Intravenous infusion of phenylephrine for 10 min…
Design
Other
Follow-up
10 minutes per infusion
Authors
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May contribute to hypertension maintenance via baroreflex impairment; hypothesis-generating for targeted interventions in essential hypertension.
Does angiotensin II infusion alter baroreflex control of muscle sympathetic nerve activity and heart rate compared to phenylephrine in hypertensive and normotensive subjects?
p-value: p=<0.05
Angiotensin II impairs baroreflex control of muscle sympathetic nerve activity and heart rate, potentially underlying the maintenance of high blood pressure in essential hypertension.
Matsukawa et al. (1988) studied Essential hypertension. Angiotensin II vs. Phenylephrine was evaluated on Blood pressure, heart rate, and muscle sympathetic nerve activity (p=<0.05). Angiotensin II infusion enhanced pressor responses in hypertensive patients compared to normotensives (P<0.05) and impaired baroreflex control of muscle sympathetic nerve activity and heart rate.
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