Key result
Intravenous infusion of angiotensin II significantly increased muscle sympathetic nerve activity compared to phenylephrine when central venous pressure was maintained.
Why the study?
Does intravenous angiotensin II stimulate sympathetic outflow compared to phenylephrine in normal humans?
Population
normal humans
Comparison
intravenous infusions of angiotensin II for 15… vs intravenous infusions of phenylephrine for 15…
Follow-up
15 min
Authors
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Hypothesis-generating for angiotensin II sympathoexcitation in humans; leaves open relevance to hypertension or HF before clinical consideration.
Does intravenous angiotensin II stimulate sympathetic outflow compared to phenylephrine in normal humans?
Angiotensin II stimulates sympathetic outflow without mediating baroreceptor reflexes in normal humans.
Matsukawa et al. (1991) studied Normal humans. Angiotensin II (ANG II) vs. Phenylephrine was evaluated on Muscle sympathetic nerve activity (MSNA) and baroreflex slope. Intravenous infusion of angiotensin II significantly increased muscle sympathetic nerve activity compared to phenylephrine when central venous pressure was maintained.
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