Why the study?
Does alpha-receptor blockade with phentolamine reduce the vasoconstrictive effect of Angiotensin II compared to sodium nitroprusside in healthy volunteers?
Population
8 healthy volunteers
Comparison
Intra-arterial infusion of Angiotensin II… vs Intra-arterial infusion of Angiotensin II…
Design
Other
Authors
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Attenuated Ang II vasoconstriction with alpha-blockade; supports sympathetic mediation but leaves open clinical relevance.
Does alpha-receptor blockade with phentolamine reduce the vasoconstrictive effect of Angiotensin II compared to sodium nitroprusside in healthy volunteers?
A significant part of the vasoconstrictive action of exogenous Angiotensin II on forearm resistance vessels in humans is sympathetically mediated.
Lyons et al. (1995) studied this question.
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