September 1, 1991Hypertension
Vascular renin-angiotensin system and neurotransmission in hypertensive persons.
Why the study?
Does a local vascular renin-angiotensin system modulate sympathetic activity in hypertensive individuals?
Population
Hypertensive individuals undergoing forearm physiological studies
Comparison
Intra-arterial infusions of isoproterenol… vs Baseline or control conditions
Design
Other
Authors
Discussion
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Member takes
Implication
Suggests local vascular RAS modulates sympathetic activity in hypertension; leaves open clinical translation and therapeutic relevance.
Structured PICO
Does a local vascular renin-angiotensin system modulate sympathetic activity in hypertensive individuals?
P
Population
Hypertensive individuals undergoing forearm physiological studies (n=5, 5, 10, and 6 in various experimental protocols)
I
Intervention
Intra-arterial infusions of isoproterenol, captopril, angiotensin II, and norepinephrine, as well as application of lower body negative pressure
C
Comparator
Baseline or control conditions (e.g., without captopril, or with propranolol)
O
Outcome
Forearm balance of active and inactive renin, angiotensin II, and norepinephrine (venous-arterial differences corrected for forearm blood flow), and forearm vasoconstrictionsurrogate
The study demonstrates the existence of a local vascular renin-angiotensin system in hypertensive patients that modulates sympathetic activity via presynaptic facilitation of norepinephrine release.
Cite This Study
Taddei et al. (1991) studied this question.