September 1, 1991Canadian Journal of Physiology and Pharmacology
Active and inactive renin in human forearm of hypertensive patients
Why the study?
Does beta-adrenoceptor stimulation with isoproterenol cause local active and inactive renin production in the forearm vascular bed of hypertensive patients?
Population
10 hypertensive patients
Comparison
Isoproterenol infused into the brachial artery… vs Intra-arterial propranolol pretreatment in a…
Design
Other
Follow-up
Acute (during infusion)
Authors
Discussion
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Member takes
Implication
Local beta-adrenoceptor stimulation may drive forearm renin release in hypertension; leaves open clinical relevance and requires confirmation.
Structured PICO
Does beta-adrenoceptor stimulation with isoproterenol cause local active and inactive renin production in the forearm vascular bed of hypertensive patients?
P
Population
10 hypertensive patients
I
Intervention
Isoproterenol infused into the brachial artery at increasing cumulative rates (0.03, 0.1, 0.3 micrograms.100 mL-1 forearm tissue.min-1 for 5 min each)
C
Comparator
Intra-arterial propranolol pretreatment (10 micrograms.100 mL-1 forearm tissue.min-1 for 10 min) in a subset (n=5)
O
Outcome
Active and inactive vessel renin production (measured by venous-arterial differences)surrogate
This study provides the first in vivo evidence in humans that beta-adrenoceptor stimulation induces local production of active and inactive renin in the forearm vascular bed.
Cite This Study
Taddei et al. (1991) studied this question.