Key result
In anesthetized pigs, stimulation and suppression of renin release resulted in parallel changes in both active and inactive renin, suggesting they are controlled by similar mechanisms.
Why the study?
Does stimulation or suppression of renin release affect the relative rates of active and inactive renin release in anesthetized pigs?
Population
Anesthetized pigs
Comparison
Stimulation of renin release with isoproterenol… vs Baseline (before stimulation or suppression)
Design
Preclinical
Authors
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Parallel renin control in pigs does not alter clinical practice; leaves open translation to human renin-angiotensin disorders.
Does stimulation or suppression of renin release affect the relative rates of active and inactive renin release in anesthetized pigs?
In a porcine model, the release of active and inactive renin appears to be controlled by similar mechanisms, with parallel changes occurring during both stimulation and suppression.
Bailie et al. (1979) studied this question. Pharmacological stimulation and suppression (isoproterenol, furosemide, propranolol, indomethacin) vs. Baseline was evaluated on Release rates of active and inactive renin. In anesthetized pigs, stimulation and suppression of renin release resulted in parallel changes in both active and inactive renin, suggesting they are controlled by similar mechanisms.
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