What question did this study set out to answer?

To determine how active and inactive plasma renin respond to physiological and pharmacological stimuli in healthy subjects and evaluate kallikrein's potential role in activating inactive renin.

January 1, 1982Folia Endocrinologica JaponicaOpen Access

The Responses of Active and Inactive Plasma Renin to Various Conditions in Normal Subjects and the Role of Renal or Plasma Kallikrein in Activation of Inactive Renin

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Population

Normal subjects

Authors

MNMitsuaki NakamaruKawamura Hospital TOToshio OgiharaNihon University JHJitsuo HigakiGeneral / Preventive / Lipids

Discussion

Member takes

Implication

No immediate clinical implications for renin assessment; leaves open kallikrein’s role in inactive renin activation for targeted studies.

Key Points

To determine how active and inactive plasma renin respond to physiological and pharmacological stimuli in healthy subjects and evaluate kallikrein's potential role in activating inactive renin.
Measured active renin, trypsin-activated total renin, urinary kallikrein, and plasma prekallikrein in normal subjects undergoing acute challenges (furosemide, ambulation, isoproterenol, captopril) and 4-day interventions (dietary sodium changes, propranolol).
Evaluated the effect of a continuous 3-day infusion of the serine protease inhibitor aprotinin on circulating active and inactive renin levels.
Short-term interventions (furosemide, ambulation, isoproterenol, captopril) increased active renin without altering inactive renin, while 4-day sodium balance changes induced parallel shifts in both forms.
The active-to-total renin ratio correlated significantly with urinary kallikrein during furosemide stimulation and with plasma prekallikrein during 4-day sodium balance manipulation.
Propranolol reduced active renin without altering inactive renin, and aprotinin infusion produced no significant changes in active or inactive plasma renin.

Structured PICO

Population

Normal subjects

Intervention

Various physiological and pharmacological stimuli including furosemide administration and ambulation, isoproterenol infusion, captopril administration, sodium depletion and repletion (4 days each), propranolol administration (4 days), and aprotinin infusion (3 days)

Outcome

Plasma active and inactive renin levelssurrogate

The study demonstrates that active and inactive renin have different control mechanisms and suggests that renal or plasma kallikrein is partially involved in the in vivo activation of inactive renin.

Cite This Study

Nakamaru et al. (1982) studied this question.

synapsesocial.com/papers/6a83c545f4298de60b3c2bda https://doi.org/10.1507/endocrine1927.58.8_994

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Implication

No immediate clinical implications for renin assessment; leaves open kallikrein’s role in inactive renin activation for targeted studies.

The Responses of Active and Inactive Plasma Renin to Various Conditions in Normal Subjects and the Role of Renal or Plasma Kallikrein in Activation of Inactive Renin

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

The Responses of Active and Inactive Plasma Renin to Various Conditions in Normal Subjects and the Role of Renal or Plasma Kallikrein in Activation of Inactive Renin

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider