Key result
Hypertensive or renal disease was associated with excessive excretion of active and inactive renins in some patients, with molecular weights between 45,000 and 64,000 by gel filtration.
Observational
The study demonstrates that active and inactive renins are excreted in human urine, with excessive excretion in some hypertensive or renal disease patients independent of plasma levels.
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Excessive urinary renin excretion in hypertension or renal disease is hypothesis-generating; leaves open diagnostic utility and mechanisms.
Matsunaga et al. (1982) conducted an observational in Hypertensive or renal disease. Hypertensive or renal disease vs. Normal subjects was evaluated on Urinary excretions of active and inactive renin. Hypertensive or renal disease was associated with excessive excretion of active and inactive renins in some patients, with molecular weights between 45,000 and 64,000 by gel filtration.
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