Key result
Active renin concentration strongly correlates with total renin concentration in hypertensive patients.
Why the study?
The role of inactive renin in hypertensive patients was not well understood and required assessment of active, inactive, and total renin concentrations.
Population
37 hypertensive patients of various etiologies and 59 normal subjects
Comparison
Active, inactive, and total renin concentrations among hypertensive subgroups and normal subjects
Design
Observational cross-sectional study
Authors
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Supports dual renin mechanisms in hypertension; hypothesis-generating for outcomes or therapy without prospective data.
Observational (n=96)
No
Effect estimate: r = 0.80
p-value: p=<0.001
The increase in circulating active renin in certain hypertensive states is driven by both enhanced kidney release and increased activation of inactive renin.
Goto et al. (1985) conducted an observational in Hypertension (n=96). Hypertension of various etiologies vs. Normal subjects was evaluated on Correlation between active renin concentration (ARC) and total renin concentration (TRC) (r = 0.80, p=<0.001). In hypertensive patients, active renin concentration showed a close positive correlation with total renin concentration (r = 0.80, p < 0.001) and active renin ratio (r = 0.71, p < 0.001).
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