Key result
Furosemide activates inactive renin while captopril promotes active renin release in renovascular hypertension.
Why the study?
The mechanisms underlying changes in active and inactive renin levels induced by captopril, furosemide, PTA, and nephrectomy in hypertensive patients were not fully understood.
How do various maneuvers including captopril, furosemide, PTA, and nephrectomy affect active and inactive renin levels in hypertensive patients?
Comparison
Captopril (n=29) vs furosemide (n=10) administration; PTA and nephrectomy in select cases
Design
Observational study measuring renin changes after pharmacologic and interventional maneuvers
Authors
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The study suggests that furosemide increases active renin partly by activating inactive renin in renovascular hypertension, while captopril promotes active renin release, and inactive renin has a slower metabolic clearance than active renin.
How do various maneuvers including captopril, furosemide, PTA, and nephrectomy affect active and inactive renin levels in hypertensive patients?
The study suggests that furosemide increases active renin partly by activating inactive renin in renovascular hypertension, while captopril promotes active renin release, and inactive renin has a slower metabolic clearance than active renin.
Goto et al. (1986) studied Hypertension (n=43). Captopril or Furosemide vs. Baseline (recumbent position) was evaluated on Changes in active and inactive renin concentration. In patients with renovascular hypertension, inactive renin was markedly decreased by furosemide but unchanged by captopril despite significant increases in active renin, suggesting furosemide activates inactive renin while captopril promotes active renin release.
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