Key result
Captopril acutely increases active and reduces inactive renin, but chronically elevates both in normal subjects.
Why the study?
The time course and reciprocal changes of active and inactive renin after converting enzyme inhibition in normal humans were not fully characterized.
Does captopril alter active and inactive renin levels in normal volunteers and patients with renal insufficiency?
Comparison
Baseline renin levels vs after captopril administration
Design
Interventional study with acute and chronic phases in normal and renal impaired subjects
Follow-up
3 days
Authors
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ACE inhibition's acute/chronic renin effects warrant no practice change; leaves open inactive renin as precursor pending patient studies.
Does captopril alter active and inactive renin levels in normal volunteers and patients with renal insufficiency?
p-value: p=<0.02
Converting enzyme inhibition acutely increases active renin while reciprocally reducing inactive renin, and chronically increases both, supporting the hypothesis that inactive renin is a precursor to active renin.
Goldstone et al. (1983) studied Normal physiology and renal insufficiency with hyporeninemic hypoaldosteronism (n=10). Captopril vs. Baseline was evaluated on Changes in active and inactive renin (p=<0.02). Captopril acutely increased active renin while reciprocally reducing the inactive form, and chronically increased both active and inactive renin in normal subjects.
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