Why the study?
Does acute captopril administration reduce blood pressure and converting enzyme activity in normotensive and hypertensive rats?
Population
Normotensive and hypertensive rat models
Comparison
Oral administration of captopril (0.3-10 mg/kg) vs Untreated state / baseline
Design
Preclinical
Follow-up
60 minutes
Authors
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Captopril response is renin-dependent in rat models; leaves open whether this guides human hypertension therapy.
Does acute captopril administration reduce blood pressure and converting enzyme activity in normotensive and hypertensive rats?
Acute captopril administration completely blocks plasma converting enzyme activity and reduces blood pressure specifically in rat models with high plasma renin activity.
Levens et al. (1981) studied this question.
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