Why the study?
Does oral captopril alter blood pressure and brain angiotensin-converting enzyme activity in spontaneously hypertensive rats?
Population
Spontaneously hypertensive rats of the Okamoto strain
Design
Preclinical
Follow-up
seven days
Authors
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Cautions against clinical extrapolation from rat data; extends preclinical evidence for central RAS effects in hypertension.
Does oral captopril alter blood pressure and brain angiotensin-converting enzyme activity in spontaneously hypertensive rats?
In spontaneously hypertensive rats, captopril lowers blood pressure and alters brain angiotensin-converting enzyme activity, suggesting an effect on the brain renin-angiotensin system.
Nicolantonio et al. (1984) studied this question.
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