Why the study?
Does captopril alter blood pressure and tissue norepinephrine concentrations in normotensive rats?
Does captopril alter blood pressure and tissue norepinephrine concentrations in normotensive rats?
In normotensive rats, chronic captopril administration lowers blood pressure and heart weight while increasing cardiac norepinephrine concentrations, suggesting a complex interaction with the sympathetic nervous system.
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Hypothesis-generating in normotensive rat models; leaves open any clinical relevance to human hypertension therapy.
Hirata et al. (1981) studied this question.
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