Why the study?
Does captopril affect heart rate and blood pressure in untreated hypertensive patients?
Population
88 untreated hypertensives
Design
Cohort
Follow-up
Measured every 30 minutes after administration
Authors
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Captopril was associated with BP reduction absent reflex tachycardia in hypertensives; hypothesis-generating and should not yet change practice.
Does captopril affect heart rate and blood pressure in untreated hypertensive patients?
Captopril effectively lowers blood pressure without inducing reflex tachycardia in untreated hypertensive patients.
Imai et al. (1981) studied this question.
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