Key result
A single 25 mg oral dose of captopril caused a marked rise in plasma renin concentration (>2.5 ng/ml/hr) in 7 of 8 patients with renal hypertension, compared to 0 of 10 with essential hypertension.
Why the study?
Does a single oral dose of captopril help identify patients with renovascular hypertension by altering blood pressure and plasma renin levels?
Population
24 untreated patients on a normal sodium diet, comprising essential hypertension, accelerated hypertension…
Design
Cross-sectional
Follow-up
4 hours
Authors
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May support captopril renin testing to identify renovascular hypertension; leaves open diagnostic adoption pending prospective validation.
Does a single oral dose of captopril help identify patients with renovascular hypertension by altering blood pressure and plasma renin levels?
A single oral dose of captopril induces a marked rise in plasma renin concentration in patients with renovascular disease, suggesting its utility as a diagnostic test for renovascular hypertension.
McGrath et al. (1981) studied Essential, accelerated, and renal hypertension (n=24). Captopril vs. Essential and accelerated hypertension groups was evaluated on Blood pressure and plasma renin concentration response. A single 25 mg oral dose of captopril caused a marked rise in plasma renin concentration (>2.5 ng/ml/hr) in 7 of 8 patients with renal hypertension, compared to 0 of 10 with essential hypertension.
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