Why the study?
Does captopril 50 mg provoke an exaggerated plasma renin activity response in patients with renovascular hypertension compared to normotensive and essential hypertensive patients?
Does captopril 50 mg provoke an exaggerated plasma renin activity response in patients with renovascular hypertension compared to normotensive and essential hypertensive patients?
The captopril provocation test is a useful screening procedure for diagnosing renovascular hypertension due to an exaggerated renin secretion response.
May support captopril test for renovascular hypertension screening; leaves open prospective validation in larger cohorts.
Captopril (SQ 14225), an orally active converting enzyme inhibitor, was administered in a dose of 50 mg to 12 normotensive subjects (Group I), 26 essential hypertensive patients (Group II), and 8 renovascular hypertensive patients (Group III). In Group III, 5 of the 8 patients had control plasma renal activity (PRA) similar to those in Groups I and II patients, but the PRA response to the administration of captopril was greater in 7 of the 8 patients than those in Groups I and II. These 7 patients had either bilateral or unilateral main renal artery stenosis. Captopril caused no increase in PRA in the remaining 1 who had unilateral renal artery stenosis with contralateral renin aplasia. It is concluded that this provocation test is useful as a screening procedure for the diagnosis of renovascular hypertension.
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Imai et al. (1980) studied this question.
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