Why the study?
Does a single oral dose of captopril 50 mg provoke a greater increase in plasma renin activity in patients with renovascular hypertension compared to those with essential hypertension or normotension?
Does a single oral dose of captopril 50 mg provoke a greater increase in plasma renin activity in patients with renovascular hypertension compared to those with essential hypertension or normotension?
A single 50 mg oral dose of captopril elicits a hyperresponsive increase in plasma renin activity in patients with renovascular hypertension, making it a useful diagnostic screening test.
May support captopril test for renovascular hypertension screening; hypothesis-generating and requires prospective validation.
Orally active converting enzyme inhibitor (Captopril, SQ 14225) was administered in a dose of 50 mg to 12 normotensive subjects (Group I), 26 essential hypertensive patients (Group II) and 8 renovascular hypertensive patients (Group III). In Group III, 5 of 8 patients had control plasma renin activity (PRA) similar to those in Group I and II patients, but the PRA response to the administration of Captopril was greater in 7 of 8 patients than that in Groups I and II. These 7 patients had either bilateral or unilateral main renal artery stenosis. Captopril caused no increase in PRA in the remaining 1 who had unilateral renal artery stenosis with contralateral renal aplasia. It is concluded that this provocation test is useful as a screening procedure for the diagnosis of renovascular hypertension.
No takes yet. Share an insight, caveat, or question.
Lmai et al. (1980) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: