Why the study?
Does captopril reduce blood pressure in patients with essential or renovascular hypertension?
Population
15 patients with diastolic blood pressure over 95 mm Hg after receiving a placebo for 3 days.
Comparison
Captopril given in ascending doses for periods… vs Placebo.
Design
Case_series
Follow-up
3 days to 12 months
Authors
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Early case data support captopril for BP reduction in hypertension; hypothesis-generating and requires randomized confirmation before practice change.
Does captopril reduce blood pressure in patients with essential or renovascular hypertension?
Captopril effectively lowers blood pressure in patients with essential or renovascular hypertension primarily by reducing total peripheral resistance.
Sullivan et al. (1979) studied this question.
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