Key result
Captopril 100 mg reduced mean supine blood pressure to 106/54 mm Hg at 24 hours in fluid-depleted anephric patients, compared to an increase to 134/82 mm Hg with placebo.
Why the study?
Does captopril reduce blood pressure in fluid-depleted and fluid-replete anephric patients?
Population
7 anephric patients
Comparison
Captopril 100 mg orally, given one hour after… vs Placebo
Design
RCT, Randomised cross-over, double-blind
Follow-up
24 hours
Authors
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Supports captopril for BP control in fluid-depleted anephric patients; challenges renin-only mediation of ACE-inhibitor effects.
RCT (n=7)
Double-blind
Cross-over
Does captopril reduce blood pressure in fluid-depleted and fluid-replete anephric patients?
Captopril lowers blood pressure in fluid-depleted anephric patients despite extremely low renin levels, suggesting its hypotensive effect does not depend solely on circulating renin.
Veld et al. (1980) conducted an RCT in Anephric patients (n=7). Captopril vs. Placebo was evaluated on Supine blood pressure. Captopril 100 mg reduced mean supine blood pressure to 106/54 mm Hg at 24 hours in fluid-depleted anephric patients, compared to an increase to 134/82 mm Hg with placebo.
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