Why the study?
Does a single oral dose of captopril acutely reduce blood pressure and alter circulating hormone levels in normal subjects and patients with essential hypertension?
Population
30 subjects (8 normal subjects, 6 salt-depleted normal subjects, and 16 patients with essential hypertension)
Design
Cohort
Follow-up
90 minutes
Authors
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Supports targeted acute BP lowering with captopril in salt-depleted states; hypothesis-generating for limited RAS role in untreated essential hypertension.
Does a single oral dose of captopril acutely reduce blood pressure and alter circulating hormone levels in normal subjects and patients with essential hypertension?
A single dose of captopril acutely reduces blood pressure in salt-depleted subjects and diuretic-treated hypertensive patients, but not in salt-replete or untreated hypertensive patients, suggesting the renin-angiotensin system does not play a primary role in essential hypertension.
Millar et al. (1981) studied this question.
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