Why the study?
Does captopril alter the blood pressure and renal responses to acute saline loading in normal and essential hypertensive subjects?
Population
Normal subjects and patients with normal renin essential hypertension
Comparison
Captopril administration combined with acute… vs Response to acute isotonic volume expansion…
Design
Other
Authors
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May modify volume responses in hypertension; leaves open effects on outcomes or other ACE inhibitors.
Does captopril alter the blood pressure and renal responses to acute saline loading in normal and essential hypertensive subjects?
Captopril lowers baseline blood pressure but exaggerates the blood pressure increase and blunts the natriuretic response to acute volume expansion in essential hypertension.
Mimran et al. (1982) studied this question.
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