Why the study?
Does captopril decrease blood pressure and interfere with sympathetic neural activity in essential hypertensive patients with low or normal plasma renin activity?
Population
12 essential hypertensive patients with low or normal plasma renin activity
Comparison
Captopril 150-450 mg/day vs Baseline (pre-treatment)
Design
Case_series
Authors
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Captopril may modulate sympathetic activity in low-renin hypertension; hypothesis-generating and should not yet change practice.
Does captopril decrease blood pressure and interfere with sympathetic neural activity in essential hypertensive patients with low or normal plasma renin activity?
Captopril lowers blood pressure in a subset of low/normal renin hypertensive patients, potentially through modulation of autonomic nervous system activity.
Esposti et al. (1981) studied this question.
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