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January 1, 1996Blood Pressure

Low Dose of ACE-Inhibitor Enhances Sodium Excretion in Volume Expanded Patients with Borderline Hypertension

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Why the study?

Does captopril enhance sodium excretion in volume-expanded patients with borderline hypertension?

Population

n=35 patients with borderline hypertension (BHT)

Comparison

Captopril 12.5 mg or 50 mg twice a day for 7… vs Placebo for 7 days, followed by acute saline…

Design

RCT, randomly allocated

Follow-up

7 days

Authors

CBClaudio BorghiPreventive CardiologySBStefano BoschiUniversity of PaduaFCF. V. CostaAzienda Usl Toscana Centro

Discussion

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Overview

Low-dose captopril may aid volume management in borderline hypertension; extends evidence for dose-specific natriuretic effects of ACE inhibition.

Structured PICO

Does captopril enhance sodium excretion in volume-expanded patients with borderline hypertension?

P
Population
n=35 patients with borderline hypertension (BHT)
I
Intervention
Captopril 12.5 mg (LD-CAP) or 50 mg (HD-CAP) twice a day for 7 days, followed by acute saline infusion (0.40 ml/min/kg for 45 min and 0.15 ml/min/kg for 75 min)
C
Comparator
Placebo for 7 days, followed by acute saline infusion
O
Outcome
Pressor, vascular and humoral response to acute extracellular volume expansion (including urinary sodium excretion, SBP, DBP, FVR, VV(30), PRA, plasma aldosterone)surrogate

Low-dose captopril enhances the natriuretic response to acute volume expansion in borderline hypertensives without causing hemodynamic changes.

Cite This Study

Borghi et al. (1996) studied this question.

synapsesocial.com/papers/6a6f92c784cc45bb7bdfa3afhttps://doi.org/10.3109/08037059609062116
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Importance of Plasma Renin Activity Suppression and Venous Distensibility on Pressor and Natriuretic Responses to Intravenous Salt Load in Borderline Hypertension1988 · 6 citations
  2. 2Blunting of atrial natriuretic factor response to volume expansion by benazepril in hypertensive patients1989 · 5 citations
  3. 3Kidney, salt intake, and Na+,K(+)-ATPase inhibitors in hypertension. 1990 Corcoran Lecture.1991 · 38 citations
  4. 4Genetic Influences on the Response to Dietary Salt Reduction, Acute Salt Loading, or Salt Depletion in Humans1988 · 49 citations
  5. 5Renal Hemodynamics and the Renin–Angiotensin–Aldosterone System in Normotensive Subjects with Hypertensive and Normotensive Parents1991 · 122 citations