Why the study?
Does the addition of hydrochlorothiazide to captopril enhance antihypertensive activity in spontaneously hypertensive rats?
Population
Spontaneously hypertensive rats (SHR)
Comparison
Hydrochlorothiazide plus captopril vs Captopril alone or Hydrochlorothiazide alone
Design
Preclinical
Follow-up
2 days
Authors
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HCTZ may potentiate captopril in hypertensive rats; leaves open translation to human hypertension management.
Does the addition of hydrochlorothiazide to captopril enhance antihypertensive activity in spontaneously hypertensive rats?
The potentiating effect of hydrochlorothiazide on captopril's antihypertensive activity is likely due to shifting the blood pressure maintenance system to a renin-dependent state rather than altering vascular reactivity.
Lai et al. (1982) studied this question.
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