Why the study?
Does the combination of captopril and hydrochlorothiazide synergistically reduce mean arterial blood pressure in spontaneously hypertensive rats?
Population
Spontaneously hypertensive rats (SHR)
Comparison
Combination of captopril 30 mg/kg/day and… vs Captopril alone or HCTZ alone
Design
Preclinical
Follow-up
2 days
Authors
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Hypothesis-generating for captopril-HCTZ synergy in rat models; leaves open human translation.
Does the combination of captopril and hydrochlorothiazide synergistically reduce mean arterial blood pressure in spontaneously hypertensive rats?
The synergistic antihypertensive effect of captopril and hydrochlorothiazide is mediated by increased renin dependency, enhancing responsiveness to ACE inhibition.
Chan et al. (1982) studied this question.
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