Why the study?
Does the combination of captopril and hydrochlorothiazide affect metabolic indexes and blood pressure in mild to moderate hypertensive outpatients?
Population
20 mild to moderate hypertensive outpatients
Design
Cohort
Follow-up
16 weeks
Authors
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Supports metabolic benefits of captopril-hydrochlorothiazide in hypertension; leaves open confirmation in randomized trials before practice change.
Does the combination of captopril and hydrochlorothiazide affect metabolic indexes and blood pressure in mild to moderate hypertensive outpatients?
The fixed combination of captopril and hydrochlorothiazide effectively lowers blood pressure without adverse metabolic effects, potentially improving the coronary risk profile in hypertensive patients.
Perani et al. (1990) studied this question.
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