Key result
Hydrochlorothiazide shows no significant difference vs. captopril in lowering fasting glucose in essential hypertension.
Why the study?
The metabolic effects of hydrochlorothiazide and captopril on glucose and lipid metabolism in hypertensive patients were not well characterized.
Does hydrochlorothiazide compared to captopril improve fasting glucose and lipid profiles in patients with essential hypertension?
Observational (n=660)
Systematic random sampling
No
Does hydrochlorothiazide compared to captopril improve fasting glucose and lipid profiles in patients with essential hypertension?
In patients with essential hypertension, hydrochlorothiazide and captopril produced modest, mostly non-significant reductions in fasting glucose and lipids over 12 weeks, though hydrochlorothiazide significantly reduced total cholesterol.
Answers are grounded in this paper and cite their sources.
No significant metabolic changes with either drug over 12 weeks; leaves open longer-term effects and population-specific impacts.
Objective: This study aims to compare the effects of hydrochlorothiazide and captopril on glucose and lipid metabolism in hypertensive patients. Study Design: Prospective Observational. Setting: Hayatabad Medical Complex Peshawar. Period: December 2022 to May 2023. Material & Methods: Approach was employed to investigate the metabolic impact of these antihypertensive medications. Involving a cohort of 660 hypertensive individuals. Data collection spanned over 12-week duration, with fasting glucose and lipid profiles assessed at baseline and 4, 8, and 12 weeks. Participants were categorized into hydrochlorothiazide and captopril groups, receiving standardized dosages of 25 mg/day and 50 mg/day, respectively. Fasting blood samples were analyzed for glucose and lipid parameters. Statistical analyses included paired t-tests and subgroup comparisons. Results: Both groups exhibited reductions in fasting glucose and lipid levels; however, these changes were not statistically significant within the 12-week timeframe. Comparison with national and international studies underscores population-specific variations in antihypertensive effects on metabolism. Conclusion: This study provides insights into the metabolic effects of hydrochlorothiazide and captopril among hypertensive patients. While immediate changes were not significant, the study contributes to the body of knowledge and calls for further research with extended follow-up and broader participant cohorts.
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Jamil et al. (2023) conducted an observational in Essential hypertension (n=660). Hydrochlorothiazide vs. Captopril 50 mg/day was evaluated on Fasting glucose at 12 weeks (mg/dL) (p=>0.05). In patients with essential hypertension, hydrochlorothiazide and captopril produced modest but non-significant reductions in fasting glucose levels over 12 weeks.
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