Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
October 1, 1979The Medical Journal of Australia

Comparison of the Hormonal Effects of Captopril (Sq 14225) and Hydrochlorothiazide in the Treatment of Essential Hypertension

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does captopril reduce blood pressure and alter hormonal profiles in patients with essential hypertension?

Population

20 patients with essential hypertension

Comparison

Captopril or hydrochlorothiazide for 4 weeks… vs Hydrochlorothiazide or captopril during the…

Design

Cohort

Follow-up

12 weeks

Authors

CJC. I. JohnstonUniversity of Newcastle AustraliaBMBarry P. McGrathMonash Medical CentrePMP. G. MatthewsAustin Health

Discussion

Loading...

Member takes

Implication

Supports ACEI BP reduction via RAS inhibition without bradykinin rise in essential hypertension; leaves open generalizability and requires randomized confirmation.

Structured PICO

Does captopril reduce blood pressure and alter hormonal profiles in patients with essential hypertension?

P
Population
20 patients with essential hypertension
I
Intervention
Captopril or hydrochlorothiazide for 4 weeks, followed by combination therapy with both drugs for 8 weeks
C
Comparator
Hydrochlorothiazide (for patients initially receiving captopril) or captopril (for patients initially receiving hydrochlorothiazide) during the initial 4-week phase
O
Outcome
Changes in blood pressure (supine and erect systolic and diastolic) and hormonal levels (plasma angiotensin II, aldosterone excretion, angiotensin I, plasma renin concentration, and venous bradykinin)surrogate

Captopril effectively lowers blood pressure and inhibits the renin-angiotensin system in essential hypertension, and its hypotensive effect does not appear to rely on increased circulating bradykinin.

Cite This Study

Johnston et al. (1979) studied this question.

synapsesocial.com/papers/6a7bcfd37d243c1b87ed13echttps://doi.org/10.5694/j.1326-5377.1979.tb127301.x
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Effect of the Converting Enzyme Inhibitor SQ 20.881 on Kinins, Renin‐Angiotensin‐Aldosterone and Catecholamines in Relation to Blood Pressure in Hypertensive Patients1978 · 48 citations
  2. 2Antihypertensive Effect of the Oral Angiotensin Converting-Enzyme Inhibitor SQ 14225 in Man1978 · 604 citations
  3. 3Renin—angiotensin and Kallikrein—kinin Systems in Sodium Homeostasis and Hypertension in Rats1976 · 28 citations
  4. 4Inhibition of Renin Secretion by Angiotensin .II.1965 · 197 citations