Why the study?
Does the combination of captopril and hydrochlorothiazide alter their individual pharmacokinetics or biological effects in patients with moderate essential hypertension?
Population
25 patients with moderate essential hypertension and normal renal function
Comparison
Combination of captopril 50 mg +… vs Captopril 50 mg once daily alone or…
Design
Cohort
Follow-up
45 days
Authors
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Supports non-interaction basis for longer duration; leaves open alternative mechanisms in moderate hypertension.
Does the combination of captopril and hydrochlorothiazide alter their individual pharmacokinetics or biological effects in patients with moderate essential hypertension?
The longer duration of antihypertensive action of captopril plus hydrochlorothiazide compared to captopril alone is not due to a pharmacokinetic or biological interaction between the two drugs.
Jf et al. (1987) studied this question.
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