Why the study?
Does the addition of hydrochlorothiazide or propranolol to captopril reduce blood pressure in patients with moderate to severe hypertension?
Population
24 patients with moderate to severe hypertension
Comparison
Addition of hydrochlorothiazide or propranolol… vs Captopril alone
Design
Cohort
Follow-up
4 weeks (initial captopril phase)
Authors
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May support adding hydrochlorothiazide but not propranolol to captopril; leaves open causal confirmation in randomized trials.
Does the addition of hydrochlorothiazide or propranolol to captopril reduce blood pressure in patients with moderate to severe hypertension?
In patients with hypertension treated with captopril, adding a diuretic lowers blood pressure further, whereas adding a beta-blocker does not.
MacGregor et al. (1982) studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: