Why the study?
Does captopril plus a thiazide diuretic improve blood pressure reduction compared to propranolol plus a diuretic in patients with mild to moderate essential hypertension uncontrolled by diuretics alone?
Population
270 patients with mild to moderate essential hypertension previously uncontrolled with diuretics alone.
Comparison
Captopril 37.5-75 mg/day plus a continued… vs Propranolol 60-120 mg/day plus a continued…
Design
RCT, randomized, double-blind
Follow-up
12 weeks
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Favors captopril-thiazide over propranolol-diuretic for mild-moderate hypertension; extends evidence supporting ACE inhibitors as preferred add-on therapy.
Does captopril plus a thiazide diuretic improve blood pressure reduction compared to propranolol plus a diuretic in patients with mild to moderate essential hypertension uncontrolled by diuretics alone?
Low-dose captopril combined with a thiazide diuretic is more effective and better tolerated than propranolol plus a diuretic for treating mild to moderate essential hypertension.
A 1985 study studied this question.
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