June 1, 1981Archives of Internal Medicine

Efficacy of an Oral Angiotensin-Converting Enzyme Inhibitor (Captopril) in Severe Hypertension

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Why the study?

Does captopril improve blood pressure in patients with severe refractory hypertension?

Population

10 patients with severe refractory hypertension.

Design

Case_series

Follow-up

short- and long-term periods

Authors

AZAndrew J. ZweiflerMichigan Medicine

Discussion

Member takes

Implication

May support captopril triple therapy in refractory hypertension; leaves open confirmation in randomized trials.

Structured PICO

Does captopril improve blood pressure in patients with severe refractory hypertension?

Population

10 patients with severe refractory hypertension (supine diastolic blood pressure >100 mm Hg despite a regimen of propranolol, hydralazine, and hydrochlorothiazide).

Intervention

Captopril alone, followed by the sequential addition of hydrochlorothiazide, and then propranolol.

Outcome

Blood pressure normalizationsurrogate

Captopril is effective in managing severe refractory hypertension when used in combination with hydrochlorothiazide and propranolol.

Cite This Study

Andrew J. Zweifler (1981) studied this question.

synapsesocial.com/papers/6a73f72d5be7b22ab71ee811 https://doi.org/10.1001/archinte.1981.00340070087018

Topics

Hypertension management

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Efficacy of an Oral Angiotensin-Converting Enzyme Inhibitor (Captopril) in Severe Hypertension

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Efficacy of an Oral Angiotensin-Converting Enzyme Inhibitor (Captopril) in Severe Hypertension

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider