Key result
Acute captopril lowers BP in accelerated and renal hypertension, correlating with pretreatment renin and angiotensin II.
Why the study?
Does acute captopril administration alter blood pressure and vasoactive hormones in patients with essential, accelerated, and renal hypertension?
Population
30 patients with hypertension, including essential (n=10), accelerated (n=6), and renal hypertension (n=14).
Design
Cohort
Follow-up
acute
Authors
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Acute captopril response may identify renin-dependent hypertension; leaves open whether renin profiling guides therapy selection.
Does acute captopril administration alter blood pressure and vasoactive hormones in patients with essential, accelerated, and renal hypertension?
Acute captopril administration significantly lowers blood pressure in accelerated and renal hypertension, and the resulting rise in renin may serve as a useful screening test for renovascular hypertension.
McGrath et al. (1980) studied Hypertension (essential, accelerated, and renal) (n=30). Captopril was evaluated on Acute changes in blood pressure, renin, angiotensin, bradykinin and catecholamines. Captopril acutely reduced blood pressure in accelerated and renal hypertension, with the fall positively correlated with pretreatment renin and angiotensin II.
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