Key result
Captopril transiently lowers adrenal angiotensin II receptor concentration by ~18% in rats.
Population
Rats (n=10 for 2-day treatment group) and anaesthetized dogs (n=8)
Comparison
Captopril vs Control animals
Design
Preclinical
Follow-up
Up to 5 days in rats; 15 min in dogs
Authors
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Transient adrenal receptor downregulation with captopril in rats; hypothesis-generating and should not alter human ACE inhibitor use.
Absolute Event Rate: 131% vs 160%
p-value: p=<0.01
Captopril induces transient secondary changes in angiotensin receptors and vascular reactivity, and its hypotensive effect may be partly mediated by increased intrarenal bradykinin.
Clappison et al. (1980) studied this question. Captopril vs. Controls was evaluated on Adrenal angiotensin II receptor concentration at 2 days (fmol/mg protein) (p=<0.01). Captopril treatment in rats transiently decreased adrenal angiotensin II receptor concentration from 160 to 131 fmol/mg protein at 2 days (P<0.01).
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